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Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells

21 Mar 2014

Abstract excerpt

The decline in mesenchymal stem cell (MSC) self-renewal and function with aging contributes to diseases associated with impaired osteogenesis. MSC donor age in prolonged culture also limits the therapeutic potential of these cells for tissue engineering and regenerative medicine. Here, we demonstrate an intervention to preserve the immature state MSC and consequently maintain self-renewal and differentiation...

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PMID: 24659476
DOI: 10.1002/stem.1709

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