Article
Carcinogens that induce the A:T > T:A nucleotide substitutions in the genome.
Frontiers of medicine - 1 Apr 2018
Zhou Guangbiao, Zhao Xinchun
Abstract excerpt
Recently, Ng et al. reported that the A:T > T:A substitutions, proposed to be a signature of aristolochic acid (AA) exposure, were detected in 76/98 (78%) of patients with hepatocellular carcinoma (HCC) from the Taiwan Province of China, and 47% to 1.7% of HCCs from the Chinese mainland and other countries harbored the nucleotide changes. However, other carcinogens, e.g., tobacco carcinogens 4-aminobiphenyl and...
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