Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies.

Italian journal of pediatrics - 4 Dec 2017

Yu Di, Zhuang Zhulun, Wen Zhongyuan, Zang Xiaodong, Mo Xuming

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the hyperhomocysteinemia, which is a risk factor related to the occurrence of congenital heart defect (CHD). However, the association between MTHFR polymorphism and CHD has been inconclusive. METHODS: We conducted an updated meta-analysis to provide comprehensive evidence on the role of MTHFR A1298C polymorphism in CHD. Databases were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Confidence Intervals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Incidence

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Prognosis

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 29202788
DOI: 10.1186/s13052-017-0425-1
PMCID: PMC5715640

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies.PMID 29202788Read ↗

Association between MTHFR C677T polymorphism and congenital heart disease. A family-based meta-analysis.Semantic proximity Read ↗

Association between MTHFR polymorphisms and congenital heart disease: a meta-analysis based on 9,329 cases and 15,076 controls.Semantic proximity Read ↗

Maternal MTHFR A1298C polymorphism and risk of congenital heart disease in fetusSemantic proximity Read ↗

MTHFR C677T polymorphism and risk of congenital heart defects: evidence from 29 case-control and TDT studies.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis.Semantic proximity Read ↗

The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis.Semantic proximity Read ↗

Meta analysis of the association between MTHFR C677T polymorphism and the risk of congenital heart defects.Semantic proximity Read ↗

Association Between MTHFR C677T Polymorphism and Congenital Heart Disease.Semantic proximity Read ↗

Genetic polymorphism of methylenetetrahydrofolate reductase as a potential risk factor for congenital heart disease: A meta-analysis in Chinese pediatric population.Semantic proximity Read ↗

Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Association of MTHFR 677C > T gene polymorphism with neonatal defects: a meta-analysis of 81444 subjects.Semantic proximity Read ↗

Two Common MTHFR Gene Polymorphisms (C677T and A1298C) and Fetal Congenital Heart Disease Risk: An Updated Meta-Analysis with Trial Sequential Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.