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Article

Association of MTHFD1 G1958A (rs2236225) gene polymorphism with the risk of congenital heart disease: a systematic review and meta-analysis.

BMC medical genomics - 27 Jan 2025

Yi Kang, He Shao-E, Guo Tao, Wang Zi-Qiang, Zhang Xin, Xu Jian-Guo, Zhang Hao-Yue, Liu Wei-Guo, You Tao

Abstract excerpt

BACKGROUND: We did this study to better clarify the correlations of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1)-G1958A (rs2236225) gene polymorphism with the risk of congenital heart diseases (CHD) and its subgroups. METHODS: Relevant articles were searched in PubMed, Web of Science, Cochrane Library, Embase, CNKI, VIP database and Wanfang DATA until October 2023. We will use odds ratios (ORs) and 95%...

Read the complete abstract on PubMed

Topics

Humans
Genetic Predisposition to Disease
Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Methylenetetrahydrofolate Dehydrogenase (NADP)

Minor Histocompatibility Antigens

Polymorphism, Single Nucleotide

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39871280
DOI: 10.1186/s12920-024-02052-w
PMCID: PMC11771109

Genes

MTHFD1
VIP

Variants

rs2236225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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