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Article

Association between MTHFR C677T polymorphism and congenital heart disease. A family-based meta-analysis.

Herz - 1 Apr 2015

Li Z, Jun Y, Zhong-Bao R, Jie L, Jian-Ming L

Abstract excerpt

Congenital heart disease (CHD) is the most common type of birth defect. It is suspected that polymorphisms in folate metabolism are associated with an increased risk of CHD, but the conclusion remains unclear. Studies have reported that the MTHFR C677T polymorphism was associated with the development of structural congenital heart malformations. The objective of this study was to conduct a meta-analysis of...

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Source

Identifiers

PMID: 25256053
DOI: 10.1007/s00059-014-4144-8

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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