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Article

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.

Nature communications - 1 Dec 2017

Yao Xiaomin, Zhang Chenhong, Xing Yue, Xue Guang, Zhang Qianpeng, Pan Fengwei, Wu Guojun, Hu Yingxin, Guo Qiuhong, Lu Ailing, Zhang Xiaoming, Zhou Rongbin, Tian Zhigang, Zeng Benhua, Wei Hong, Strober Warren, Zhao Liping, Meng Guangxun

Abstract excerpt

Inflammasomes are involved in gut homeostasis and inflammatory pathologies, but the role of NLRP3 inflammasome in these processes is not well understood. Cryopyrin-associated periodic syndrome (CAPS) patients with NLRP3 mutations have autoinflammation in skin, joints, and eyes, but not in the intestine. Here we show that the intestines of CAPS model mice carrying an Nlrp3 R258W mutation maintain homeostasis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29196621
DOI: 10.1038/s41467-017-01917-2
PMCID: PMC5711854

Genes

NLRP3
CAPS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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