Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations.

European journal of immunology - 1 Mar 2010

Meng Guangxun, Strober Warren

Abstract excerpt

Mutations in the Nlrp3 (CIAS1, cryopyrin) gene are associated with cryopyrin-associated periodic syndrome, autoinflammatory diseases characterized by excessive IL-1 production and neutrophilia in blood and tissues. Recent studies with gene-targeted mice expressing mutations homologous to those fo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Carrier Proteins
Share to NLRP3 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Mutation

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20201022
DOI: 10.1002/eji.200940191
PMCID: PMC3729261

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20201022-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations.PMID 20201022Read ↗

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.Semantic proximity Read ↗

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndromeSemantic proximity Read ↗

A Knock-In Mouse Model of Cryopyrin-Associated Periodic Syndromes.Semantic proximity Read ↗

Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation.Semantic proximity Read ↗

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.Semantic proximity Read ↗

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum.Semantic proximity Read ↗

The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunitySemantic proximity Read ↗

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein.Semantic proximity Read ↗

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.Semantic proximity Read ↗

Pathogenic NLRP3 mutants forms constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β productionSemantic proximity Read ↗

[Pathophysiological mechanisms underlying cryopyrin-associated periodic syndromes: genetic and molecular basis and the inflammasome].Semantic proximity Read ↗

A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.