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Article

A Knock-In Mouse Model of Cryopyrin-Associated Periodic Syndromes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Bertoni Arinna, Prigione Ignazia, Chiesa Sabrina, Ceccherini Isabella, Gattorno Marco, Rubartelli Anna

Abstract excerpt

Autoinflammatory diseases are a group of distinct disorders characterized by recurrent fever and inflammatory manifestations predominantly mediated by cytokines of the innate immune system, particularly IL-1β, without involvement of autoantibodies or autoreactive T lymphocytes. Cryopyrin-associated periodic syndromes (CAPS), due to NLRP3 gene mutations, represent the prototype of these diseases. Owing to their...

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PMID: 37578730
DOI: 10.1007/978-1-0716-3350-2_19

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