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Article

Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation.

EMBO reports - 7 Nov 2022

Chen Kaiwen W

Abstract excerpt

Gain-of-function mutation in NLRP3 is associated with a spectrum of autoinflammatory disorders including familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and neonatal onset multisystem inflammatory disease, collectively known as cryopyrin-associated periodic syndrome (CAPS). However, the cell types mediating the pathogenesis of CAPS are not completely understood. Two studies in EMBO Reports now...

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Identifiers

PMID: 36194522
DOI: 10.15252/embr.202256091
PMCID: PMC9638862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation.PMID 36194522Read ↗

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