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Article

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT.

Cell death and differentiation - 1 Oct 2023

Kwon Yujin, Kim Jiyoon, Cho Su-Yeon, Kang Yoon Jin, Lee Jongsoo, Kwon Jaeyoung, Rhee Hyungjin, Bauer Sebastian, Kim Hyung-Sik, Lee Esak, Kim Han Sang, Jung Jae Hung, Kim Hoguen, Kim Won Kyu

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) frequently show KIT mutations, accompanied by overexpression and aberrant localization of mutant KIT (MT-KIT). As previously established by multiple studies, including ours, we confirmed that MT-KIT initiates downstream signaling in the Golgi complex. Basic leucine zipper nuclear factor 1 (BLZF1) was identified as a novel MT-KIT-binding partner that tethers MT-KIT to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37704840
DOI: 10.1038/s41418-023-01220-2
PMCID: PMC10589262

Genes

KIT
ATF6
BLZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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