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Article

Failure of daptomycin β-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium.

Diagnostic microbiology and infectious disease - 1 Feb 2018

Menon Vidthiya, Davis Rebecca, Shackel Nick, Espedido Bjorn A, Beukers Alicia G, Jensen Slade O, van Hal Sebastiaan J

Abstract excerpt

Daptomycin β-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29195768
DOI: 10.1016/j.diagmicrobio.2017.10.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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