Article
Emergence of a daptomycin-non-susceptible Enterococcus faecium strain that encodes mutations in DNA repair genes after high-dose daptomycin therapy.
BMC research notes - 1 Apr 2016
Matono Takashi, Hayakawa Kayoko, Hirai Risen, Tanimura Akira, Yamamoto Kei, Fujiya Yoshihiro, Mawatari Momoko, Kutsuna Satoshi, Takeshita Nozomi, Mezaki Kazuhisa, Ohmagari Norio, Miyoshi-Akiyama Tohru
Abstract excerpt
BACKGROUND: An increasing number of reports have documented the emergence of daptomycin-nonsusceptible Enterococcus in patients during daptomycin therapy. Even though several mechanisms for daptomycin-nonsusceptibility have been suggested, the potential genetic mutations which might contribute to the daptomycin-nonsusceptibility are not fully understood. CASE PRESENTATION: We isolated a vancomycin-susceptible,...
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