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Article

DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho-/- mice.

Cardiovascular diabetology - 1 Dec 2017

Hasegawa Yu, Hayashi Kenyu, Takemoto Yushin, Cheng Cao, Takane Koki, Lin Bowen, Komohara Yoshihiro, Kim-Mitsuyama Shokei

Abstract excerpt

BACKGROUND: The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho-/- mice. METHODS: Klotho-/- mice exhibit multiple phenotypes resembling human premature aging, including extremely shortened life span, cognitive impairment, hippocampal neurodegeneration, hair loss, muscle...

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Identifiers

PMID: 29195509
DOI: 10.1186/s12933-017-0639-y
PMCID: PMC5709858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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