Article
CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Mar 2018
Thalayasingam Nishanthi, Nair Nisha, Skelton Andrew J, Massey Jonathan, Anderson Amy E, Clark Alexander D, Diboll Julie, Lendrem Dennis W, Reynard Louise N, Cordell Heather J, Eyre Stephen, Isaacs John D, Barton Anne, Pratt Arthur G
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is a genetically complex disease of immune dysregulation. This study sought to gain further insight into the genetic risk mechanisms of RA by conducting an expression quantitative trait locus (eQTL) analysis of confirmed genetic risk loci in CD4+ T cells and B cells from carefully phenotyped patients with early arthritis who were naive to therapeutic immunomodulation. METHODS:...
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