Article

Rheumatoid arthritis susceptibility genes show pathotype-specific expression in synovial tissue of early treatment-naïve RA patients

2026-01-30

Abstract excerpt

<h4>Objectives</h4> Rheumatoid arthritis (RA) exhibits clinical and biological heterogeneity, with synovial tissue stratified into histological pathotypes: lympho-myeloid, diffuse-myeloid, and pauci-immune fibroid. Although GWAS have uncovered RA risk loci, how genetic risk relates to synovial immunopathology remains unclear. To better understand how genetic predisposition may shape divergent early disease mechan...

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Literature Corpus work: a802357b-8fb8-55cf-942d-4ec3c116df48
DOI: 10.64898/2026.01.30.26345204

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