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Article

Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis.

Immunological reviews - 1 Mar 2020

Amariuta Tiffany, Luo Yang, Knevel Rachel, Okada Yukinori, Raychaudhuri Soumya

Abstract excerpt

Rheumatoid arthritis (RA) risk has a large genetic component (~60%) that is still not fully understood. This has hampered the design of effective treatments that could promise lifelong remission. RA is a polygenic disease with 106 known genome-wide significant associated loci and thousands of small effect causal variants. Our current understanding of RA risk has suggested cell-type-specific contexts for causal...

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Identifiers

PMID: 31782165
DOI: 10.1111/imr.12827
PMCID: PMC7047592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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