Article

Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease

2025-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Many neurological diseases impact specific brain regions despite widespread expression of the disease-related protein. Spinocerebellar ataxia type 1 (SCA1) primarily affects the cerebellum, though Ataxin-1 (ATXN1) is widely expressed. We previously showed that intensified interaction between mutant ATXN1 and Capicua (CIC) drives SCA1 pathogenesis in the cerebellum, whereas ATXN1 loss augments am...

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Literature Corpus work: d7761f4e-b825-5041-802b-43dbda454674
DOI: 10.1101/2025.11.05.686788

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