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Biological roles of hepatocyte growth factor‑Met signaling from genetically modified animals (Review)

18 Oct 2017

Abstract excerpt

Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. The HGF‑Met signaling pathway contributes in a paracrine manner to the development of epithelial organs, exerts regenerative effects on the epithelium, and promotes the...

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PMID: 29188052
DOI: 10.3892/br.2017.1001

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