Article
Met signaling mutants as tools for developmental studies.
The International journal of developmental biology - 1 Jan 2000
Ponzetto C, Panté G, Prunotto' C, Ieraci A, Maina F
Abstract excerpt
The Met receptor is widely expressed in embryonic and adult epithelial tissues; its ligand (hepatocyte growth factor/scatter factor, HGF/SF) is expressed in the mesenchymal component of various organs. The generation of hgf and met null mice has revealed an essential role for this ligand-receptor pair in the development of the placenta, liver, and limb muscles. However the early lethality of the null mutants has...
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