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Article

Biology of MET: a double life between normal tissue repair and tumor progression.

1 Apr 2015

Abstract excerpt

MNNG HOS transforming gene (MET) is a class IV receptor tyrosine kinase, expressed on the surface of epithelial cells. The interaction with the hepatocyte grow factor (HGF) induces MET dimerization and the activation of multiple intracellular pathways leading to cell proliferation, anti-apoptosis, morphogenic differentiation, motility, invasion, and angiogenesis. Knock out mice have demonstrated that MET is...

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Identifiers

PMID: 25992381
DOI: 10.3978/j.issn.2305-5839.2015.03.58

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