Article

Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex

2024-05-16

Abstract excerpt

<h4>ABSTRACT</h4> The mitochondrial pyruvate carrier (MPC) plays a role in numerous diseases including neurodegeneration, metabolically dependent cancers, and the development of insulin resistance. Several previous studies in genetic mouse models or with existing inhibitors suggest that inhibition of the MPC could be used as a viable therapeutic strategy in these diseases. However, the MPC’s structure is unknown,...

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Literature Corpus work: 636acfe2-8a7f-5d19-9060-30ace12ed515
DOI: 10.1101/2024.05.16.594520

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