Article

Modelling dynamics of human NDPK hexamer structure, stability and interactions

2024-09-23

Abstract excerpt

Nucleoside diphosphate kinases (NDPKs) are evolutionarily conserved multifunctional enzymes involved in energy metabolism and gene regulation. NDPKs primarily regulate nucleotide pool turnover by catalyzing the transfer between nucleoside triphosphate (NTPs) and their deoxy derivatives, maintaining cellular homeostasis. The NDPK hexameric assembly is needed for kinase activity, but its precise assembly into homo-/...

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Literature Corpus work: 14695592-679b-5344-8da8-cd0ecded81f9
DOI: 10.1101/2024.09.19.613900

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