Article

<em>In silico</em> Analysis of PMM2 Dimer Interface Stability and Heterodimerization with PMM1

2025-05-02

Abstract excerpt

Phosphomannomutase 2 (PMM2) catalyzes the interconversion of mannose-6-phosphate and mannose-1-phosphate, a key step in the biosynthesis of GDP-mannose for N-glycosylation. Its deficiency is the most common cause of congenital disorders of glycosylation (CDG), accounting for the subtype known as PMM2-CDG. PMM2-CDG is a rare autosomal recessive disease characterized by multisystemic dysfunction. Dimerization of PMM...

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Literature Corpus work: 7a3d58ed-4701-5fce-9531-20e7963c5785
DOI: 10.20944/preprints202505.0058.v1

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