FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents.

doi:10.1007/s00429-022-02577-9

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Article

FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents.

Brain structure & function - 1 Nov 2022

Womersley Jacqueline S, Roeh Simone, Martin Lindi, Ahmed-Leitao Fatima, Sauer Susann, Rex-Haffner Monika, Hemmings Sian M J, Binder Elisabeth B, Seedat Soraya

Abstract excerpt

Dysregulation of stress response systems may mediate the detrimental effects of childhood trauma (CT) on mental health. FKBP5 regulates glucocorticoid receptor sensitivity and exerts pleiotropic effects on intracellular signaling, neurobiology and behavior. We investigated whether CT, alone and in combination with rs1360780 genotype, is associated with altered FKBP5 methylation and whether CT-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36197505
DOI: 10.1007/s00429-022-02577-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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