Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis.

Cancer research - 1 Jul 2020

Bui Ngoc H B, Napoli Marco, Davis Andrew John, Abbas Hussein A, Rajapakshe Kimal, Coarfa Cristian, Flores Elsa R

Abstract excerpt

ΔNp63 is a transcription factor of the p53 family and has crucial functions in normal development and disease. The expression pattern of ΔNp63 in human cancer suggests dynamic regulation of this isoform during cancer progression and metastasis. Many primary and metastatic tumors express high levels of ΔNp63, while ΔNp63 loss is crucial for tumor dissemination, indicating an oscillatory expression of ΔNp63 during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Spatio-Temporal Analysis

Share to Transforming Growth Factor beta

Share to Tumor Suppressor Proteins

Share to Urinary Bladder Neoplasms

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 32312834
DOI: 10.1158/0008-5472.CAN-19-2733
PMCID: PMC7385751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis.PMID 32312834Read ↗

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced MetastasisSemantic proximity Read ↗

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional programSemantic proximity Read ↗

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.Semantic proximity Read ↗

Complex and variable regulation of ΔNp63 and TAp63 by TGFβ has implications for the dynamics of squamous cell epithelial to mesenchymal transitionSemantic proximity Read ↗

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.Semantic proximity Read ↗

p53 and ΔNp63α Coregulate the Transcriptional and Cellular Response to TGFβ and BMP SignalsSemantic proximity Read ↗

TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathwaySemantic proximity Read ↗

p63-related signaling at a glanceSemantic proximity Read ↗

The p53 Family Members p63 and p73 Roles in the Metastatic Dissemination: Interactions with microRNAs and TGFβ PathwaySemantic proximity Read ↗

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.Semantic proximity Read ↗

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Semantic proximity Read ↗

Intersection of the p63 and NF‐κB pathways in epithelial homeostasis and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.