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Article

Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations.

Human pathology - 1 Feb 2018

Chianchiano Peter, Pezhouh Maryam Kherad, Kim Amy, Luchini Claudio, Cameron Andrew, Weiss Matthew J, He Jin, Voltaggio Lysandra, Oshima Kiyoko, Anders Robert A, Wood Laura D

Abstract excerpt

Patients with hepatocellular carcinoma (HCC) frequently have multiple anatomically distinct tumors. In these patients, multifocal HCC could represent intrahepatic metastases (IMs) of a single cancer or multicentric carcinogenesis (MC) with multiple independent neoplasms. To determine the frequency and clinical implications of these 2 possibilities, we performed histological and molecular analysis of 70...

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PMID: 29180252
DOI: 10.1016/j.humpath.2017.11.011
PMCID: PMC6435273

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