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Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters

23 Apr 2013

Abstract excerpt

Interindividual variability in the expression of drug-metabolizing enzymes and transporters (DMETs) in human liver may contribute to interindividual differences in drug efficacy and adverse reactions. Published studies that analyzed variability in the expression of DMET genes were limited by sample sizes and the number of genes profiled. We systematically analyzed the expression of 374 DMETs from a microarray...

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PMID: 23637747
DOI: 10.1371/journal.pone.0060368

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