Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of drug transporters in human kidney: impact of sex, age, and ethnicity

26 Feb 2015

Abstract excerpt

BACKGROUND: Differences in expression of drug transporters in human kidney contribute to changes in pharmacokinetics and toxicokinetics of a variety of drug compounds. The basal expression levels of genes involved in drug transport processes in the kidney introduces differences in bioavailability, distribution, and clearance of drugs, possibly influencing drug efficacy and adverse reactions. Sex differences in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Pharmacogenetics and Drug Metabolism

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25750709
DOI: 10.1186/s13293-015-0020-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of drug transporters in human kidney: impact of sex, age, and ethnicityPMID 25750709Read ↗

Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology.Semantic proximity Read ↗

Drug Transporter Function--Implications in CKD.Semantic proximity Read ↗

Sex Differences in the Expression of Drug-Metabolizing and Transporter Genes in Human LiverSemantic proximity Read ↗

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug DispositionSemantic proximity Read ↗

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter ConsortiumSemantic proximity Read ↗

Genetic and/or non-genetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicitySemantic proximity Read ↗

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.Semantic proximity Read ↗

Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms.Semantic proximity Read ↗

Multitissue analysis of absorption, distribution, metabolism, and excretion gene expression: Sex and age effects across human organ systemsSemantic proximity Read ↗

Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy.Semantic proximity Read ↗

Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC PerspectiveSemantic proximity Read ↗

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter ConsortiumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.