Reporter-Based Assays for High-Throughput Drug Screening against Mycobacterium abscessus

Abstract excerpt

Mycobacterium abscessus (Mab) is a non-tuberculous mycobacterium that causes pulmonary and non-pulmonary infections. Mab is resistant to many chemotherapeutic agents and the current treatment options show poor clinical outcomes. Thus, there is a dire need to find new antimicrobials effective at killing Mab. Screening drug libraries to identify potential antimicrobials has been impeded by the lack of validated HTS...

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