Article
Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.
Antimicrobial agents and chemotherapy - 1 Apr 2017
Halloum Iman, Viljoen Albertus, Khanna Varun, Craig Derek, Bouchier Christiane, Brosch Roland, Coxon Geoffrey, Kremer Laurent
Abstract excerpt
Available chemotherapeutic options are very limited against Mycobacterium abscessus, which imparts a particular challenge in the treatment of cystic fibrosis (CF) patients infected with this rapidly growing mycobacterium. New drugs are urgently needed against this emerging pathogen, but the discovery of active chemotypes has not been performed intensively. Interestingly, however, the repurposing of thiacetazone...
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