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Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

17 May 2021

Abstract excerpt

New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active against Mycobacterium tuberculosis , we previously identified the piperidine-4-carboxamide (P4C) MMV688844 (844) as a...

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PMID: 34001512
DOI: 10.1128/aac.00676-21

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