Article

Antibiotic lethality dictates mycobacterial infection outcomes

2024-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic development and treatment focus on bacterial growth inhibition, often with limited success. Here, we introduce Antimicrobial Single-Cell Testing (ASCT), an advanced imaging strategy to assess bacterial killing in real-time. By tracking 140 million bacteria and generating over 20,000 in vitro time-kill curves, we can predict Mycobacterium tuberculosis treatment outcomes in mice and h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2088da4f-e65f-54e0-b1cd-2ff27efbc062
DOI: 10.1101/2024.10.29.619904

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibiotic lethality dictates mycobacterial infection outcomesDOI 10.1101/2024.10.29.619904Read

ODELAM: Rapid sequence-independent detection of drug resistance in clinical isolates of Mycobacterium tuberculosisSemantic proximity Read

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.Semantic proximity Read

Transcriptome signature of cell viability predicts drug response and drug interaction for TuberculosisSemantic proximity Read

Phenotypic drug susceptibility testing for Mycobacterium tuberculosis variant bovis BCG in 12 hoursSemantic proximity Read

One-day phenotypic drug susceptibility testing for <i>Mycobacterium tuberculosis</i> variant <i>bovis</i> BCG using single-cell imaging and a deep neural networkSemantic proximity Read

Time-Lapse Deep Learning for Single-Cell Subcellular Structural Phenotypic Antimicrobial Susceptibility Testing.Semantic proximity Read

Stress-responsive <i>Mycobacterium tuberculosis</i> subpopulations manipulate macrophage polarization and can be targeted to limit inflammationSemantic proximity Read

Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We StandSemantic proximity Read

Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population.Semantic proximity Read

Luciferase reporter mycobacteriophage (TM4:: GeNL ) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complexSemantic proximity Read

Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosisSemantic proximity Read

Tre-DST: A new drug susceptibility test for <i>Mycobacterium tuberculosis</i> using solvatochromic trehalose probesSemantic proximity Read