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Article

CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors.

Frontiers in immunology - 1 Jan 2020

Golinski Marie-Laure, Demeules Mélanie, Derambure Céline, Riou Gaetan, Maho-Vaillant Maud, Boyer Olivier, Joly Pascal, Calbo Sébastien

Abstract excerpt

CD11c+ B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c+ B cells from healthy donors by flow cytometry, microarray analysis, and in vitro functional assays. Here, we report that CD11c+ B cells are a distinct subpopulation of B cells, enriched in the memory subpopulation even if their phenotype is...

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Identifiers

PMID: 32158442
DOI: 10.3389/fimmu.2020.00032
PMCID: PMC7051942

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