Article
Single molecule real-time DNA sequencing of HLA genes at ultra-high resolution from 126 International HLA and Immunogenetics Workshop cell lines.
HLA - 1 Feb 2018
Turner T R, Hayhurst J D, Hayward D R, Bultitude W P, Barker D J, Robinson J, Madrigal J A, Mayor N P, Marsh S G E
Abstract excerpt
The hyperpolymorphic HLA genes play important roles in disease and transplantation and act as genetic markers of migration and evolution. A panel of 107 B-lymphoblastoid cell lines (B-LCLs) was established in 1987 at the 10th International Histocompatibility Workshop as a resource for the immunog...
Topics
- Alleles
- Cell Line
- Computer Systems
- HLA Antigens
- Humans
- Immunogenetics
- Internationality
- Linkage Disequilibrium
- Sequence Analysis, DNA
- Single Molecule Imaging