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Article

Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.

Molecular cell - 14 Dec 2007

Ohi Melanie D, Feoktistova Anna, Ren Liping, Yip Calvin, Cheng Yifan, Chen Jun-Song, Yoon Hyun-Joo, Wall Joseph S, Huang Zhong, Penczek Pawel A, Gould Kathleen L, Walz Thomas

Abstract excerpt

The anaphase-promoting complex/cyclosome (APC/C) is a conserved multisubunit E3 ubiquitin (Ub) ligase required to signal the degradation of key cell-cycle regulators. Using single particle cryo-electron microscopy (cryo-EM), we have determined a three-dimensional (3D) structure of the core APC/C from Schizosaccharomyces pombe bound to the APC/C activator Slp1/Cdc20. At the 27 A resolution of our density map, the...

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Identifiers

PMID: 18082611
DOI: 10.1016/j.molcel.2007.10.003
PMCID: PMC2197158

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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