Article
Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.
Cell motility and the cytoskeleton - 1 Jan 1997
Hasson T, Walsh J, Cable J, Mooseker M S, Brown S D, Steel K P
Abstract excerpt
Numerous mammalian diseases have been found to be due to mutations in components of the actin cytoskeleton. Recently, mutations in the gene for an unconventional myosin, myosin-VIIa, were found to be the basis for the deafness and vestibular dysfunction observed in shaker-1 (sh1) mice and for a human deafness-blindness syndrome, Usher syndrome type 1B. Seven alleles of sh1 mice were analyzed to assess the affects...
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