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Ankyrins and Spectrins in Cardiovascular Biology and Disease

27 Oct 2017

Abstract excerpt

Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements. Findings in humans and animal models have highlighted the in vivo roles for ankyrins in normal physiology and in cardiovascular disease, most notably in cardiac arrhythmia. For example, human ANK2 loss-of-function variants are associated with a complex array of...

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PMID: 29163198
DOI: 10.3389/fphys.2017.00852

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