Article
Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.
Circulation - 24 Feb 2015
Smith Sakima A, Sturm Amy C, Curran Jerry, Kline Crystal F, Little Sean C, Bonilla Ingrid M, Long Victor P, Makara Michael, Polina Iuliia, Hughes Langston D, Webb Tyler R, Wei Zhiyi, Wright Patrick, Voigt Niels, Bhakta Deepak, Spoonamore Katherine G, Zhang Chuansheng, Weiss Raul, Binkley Philip F, Janssen Paul M, Kilic Ahmet, Higgins Robert S, Sun Mingzhai, Ma Jianjie, Dobrev Dobromir, Zhang Mingjie, Carnes Cynthia A, Vatta Matteo, Rasband Matthew N, Hund Thomas J, Mohler Peter J
Abstract excerpt
BACKGROUND: The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked to cardiac pathologies, including myopathies, aortopathies, and dystrophies. Conversely, the link between cytoskeletal protein dysfunction and cardiac electric activity is not well understood and often overlooked in the...
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