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Article

Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting

28 Apr 2005

Abstract excerpt

PURPOSE OF REVIEW: This review addresses a new mechanism for arrhythmia due to abnormal cellular localization of membrane ion channels and transporters. The focus is on ankyrins, a family of proteins that localize diverse membrane ion channels and transporters, and recent evidence that mutations affecting functions of ankyrins result in cardiac arrhythmia. RECENT FINDINGS: A loss-of-function mutation of ankyrin-B...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 15861006
DOI: 10.1097/01.hco.0000160372.95116.3e

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