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Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.

Biomolecules - 31 Jan 2020

Sucharski Holly C, Dudley Emma K, Keith Caullin B R, El Refaey Mona, Koenig Sara N, Mohler Peter J

Abstract excerpt

Ankyrin-B (encoded by ANK2), originally identified as a key cytoskeletal-associated protein in the brain, is highly expressed in the heart and plays critical roles in cardiac physiology and cell biology. In the heart, ankyrin-B plays key roles in the targeting and localization of key ion channels and transporters, structural proteins, and signaling molecules. The role of ankyrin-B in normal cardiac function is...

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Identifiers

PMID: 32023981
DOI: 10.3390/biom10020211
PMCID: PMC7072516

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