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Article

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008

Le Scouarnec Solena, Bhasin Naina, Vieyres Claude, Hund Thomas J, Cunha Shane R, Koval Olha, Marionneau Celine, Chen Biyi, Wu Yuejin, Demolombe Sophie, Song Long-Sheng, Le Marec Hervé, Probst Vincent, Schott Jean-Jacques, Anderson Mark E, Mohler Peter J

Abstract excerpt

The identification of nearly a dozen ion channel genes involved in the genesis of human atrial and ventricular arrhythmias has been critical for the diagnosis and treatment of fatal cardiovascular diseases. In contrast, very little is known about the genetic and molecular mechanisms underlying human sinus node dysfunction (SND). Here, we report a genetic and molecular mechanism for human SND. We mapped two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18832177
DOI: 10.1073/pnas.0805500105
PMCID: PMC2563133

Genes

ANK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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