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Article

Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation

23 Aug 2011

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting >2 million patients in the United States alone. Despite decades of research, surprisingly little is known regarding the molecular pathways underlying the pathogenesis of AF. ANK2 encodes ankyrin-B, a multifunctional adapter molecule implicated in membrane targeting of ion channels, transporters, and signaling molecules in...

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Share to Atrial Fibrillation Management and Outcomes
Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function

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PMID: 21859974
DOI: 10.1161/circulationaha.111.023986

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