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Article

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.

International journal of molecular sciences - 21 Nov 2017

Chen Chiung-Mei, Wu Yih-Ru, Chang Kuo-Hsuan

Abstract excerpt

Huntington's disease (HD) is caused by an unstable cytosine adenine guanine (CAG) trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin protein. Previously, we identified several up- and down-regulated protein molecules in the striatum of the Hdh(CAG)150 knock-in mice at 16 months of age, a mouse model which is modeling the early human HD stage. Among those molecules, aconitase 2 (Aco2)...

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Identifiers

PMID: 29160844
DOI: 10.3390/ijms18112480
PMCID: PMC5713446

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