Article
A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease.
Molecular & cellular proteomics : MCP - 1 Apr 2009
Zabel Claus, Mao Lei, Woodman Ben, Rohe Michael, Wacker Maik A, Kläre Yvonne, Koppelstätter Andrea, Nebrich Grit, Klein Oliver, Grams Susanne, Strand Andrew, Luthi-Carter Ruth, Hartl Daniela, Klose Joachim, Bates Gillian P
Abstract excerpt
Huntington disease (HD) is fatal in humans within 15-20 years of symptomatic disease. Although late stage HD has been studied extensively, protein expression changes that occur at the early stages of disease and during disease progression have not been reported. In this study, we used a large two-dimensional gel/mass spectrometry-based proteomics approach to investigate HD-induced protein expression alterations...
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