Article
Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model.
Journal of neuropathology and experimental neurology - 1 Jun 2015
Naseri Nima N, Xu Hui, Bonica Joseph, Vonsattel Jean Paul G, Cortes Etty P, Park Larry C, Arjomand Jamshid, Gibson Gary E
Abstract excerpt
Glucose metabolism is reduced in the brains of patients with Huntington disease (HD). The mechanisms underlying this deficit, its link to the pathology of the disease, and the vulnerability of the striatum in HD remain unknown. Abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase complex (PDHC) and the tricarboxylic acid (TCA) cycle, may...
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