Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysfunctional mitochondrial respiration in the striatum of the Huntington’s disease transgenic R6/2 mouse model

1 Jan 2013

Abstract excerpt

Metabolic dysfunction and mitochondrial involvement are recognised as part of the pathology in Huntington's Disease (HD). Post-mortem examinations of the striatum from end-stage HD patients have shown a decrease in the in vitro activity of complexes II, III and IV of the electron transport system (ETS). In different models of HD, evidence of enzyme defects have been reported in complex II and complex IV using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23568011
DOI: 10.1371/currents.hd.d8917b4862929772c5a2f2a34ef1c201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysfunctional mitochondrial respiration in the striatum of the Huntington’s disease transgenic R6/2 mouse modelPMID 23568011Read ↗

Mitochondrial and redox modifications in early stages of Huntington’s diseaseSemantic proximity Read ↗

Mitochondrial and redox modifications in early stages of Huntington's diseaseSemantic proximity Read ↗

Selective striatal mtDNA depletion in end-stage Huntington's disease R6/2 mice.Semantic proximity Read ↗

Oxidative metabolism in YAC128 mouse model of Huntington's disease.Semantic proximity Read ↗

High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function.Semantic proximity Read ↗

Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice.Semantic proximity Read ↗

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.Semantic proximity Read ↗

Selective defect of <i>in vivo</i> glycolysis in early Huntington's disease striatumSemantic proximity Read ↗

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouseSemantic proximity Read ↗

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.Semantic proximity Read ↗

Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation.Semantic proximity Read ↗

Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.