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Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

1 Jan 2000

Abstract excerpt

Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely expressed 349-kd protein, huntingtin. The medium spiny neurons of the caudate preferentially degenerate in Huntington's disease, with the presence of neuronal intranuclear inclusions. Excitotoxicity is thought to be important in the pathogenesis of Huntington's...

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PMID: 10632104
DOI: 10.1002/1531-8249(200001)47:1<80::aid-ana13>3.0.co;2-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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