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Article

Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases.

International journal of molecular sciences - 15 Sept 2024

Padalko Volodymyr, Posnik Filip, Adamczyk Malgorzata

Abstract excerpt

This survey reviews modern ideas on the structure and functions of mitochondrial and cytosolic aconitase isoenzymes in eukaryotes. Cumulative experimental evidence about mitochondrial aconitases (Aco2) as one of the main targets of reactive oxygen and nitrogen species is generalized. The important role of Aco2 in maintenance of homeostasis of the intracellular iron pool and maintenance of the mitochondrial DNA is...

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Identifiers

PMID: 39337438
DOI: 10.3390/ijms25189950
PMCID: PMC11431987

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