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Article

Oxidative metabolism in YAC128 mouse model of Huntington's disease.

Human molecular genetics - 1 Sept 2015

Hamilton James, Pellman Jessica J, Brustovetsky Tatiana, Harris Robert A, Brustovetsky Nickolay

Abstract excerpt

Alterations in oxidative metabolism are considered to be one of the major contributors to Huntington's disease (HD) pathogenesis. However, existing data about oxidative metabolism in HD are contradictory. Here, we investigated the effect of mutant huntingtin (mHtt) on oxidative metabolism in YAC128 mice. Both mHtt and wild-type huntingtin (Htt) were associated with mitochondria and the amount of bound Htt was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26041817
DOI: 10.1093/hmg/ddv209
PMCID: PMC4527489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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