Article
Analysis of Driver Mutational Hot Spots in Blood-Derived Cell-Free DNA of Patients with Primary Central Nervous System Lymphoma Obtained before Intracerebral Biopsy.
The Journal of molecular diagnostics : JMD - 1 Oct 2020
Montesinos-Rongen Manuel, Brunn Anna, Tuchscherer Armin, Borchmann Peter, Schorb Elisabeth, Kasenda Benjamin, Altmüller Janine, Illerhaus Gerald, Ruge Maximilian I, Maarouf Mohammad, Büttner Reinhard, Hansmann Martin-Leo, Hallek Michael, Prinz Marco, Siebert Reiner, Deckert Martina
Abstract excerpt
In newly diagnosed systemic diffuse large B-cell lymphoma, next-generation sequencing of plasma-derived cell-free DNA (cfDNA) detects somatic mutations as accurate as genotyping of the tumor biopsy. A distinct diffuse large B-cell lymphoma entity confined to the central nervous system is primary central nervous system lymphoma (PCNSL), which requires intracerebral biopsy and neuropathologic analysis to establish...
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